Case Evaluation

Acetaminophen: What is Acetaminophen

What is acetaminophen?

Acetaminophen is a pain reliever and a fever reducer used to treat many conditions such as headache, muscle aches, arthritis, backache, toothaches, colds, and fevers.

What should I discuss with my healthcare provider before taking acetaminophen?

Do not take acetaminophen without first talking to your doctor if you drink more than three alcoholic beverages per day or if you have had alcoholic liver disease. You may not be able to take acetaminophen, or you may require a lower dose or special monitoring. Before taking acetaminophen, tell your doctor if you have kidney or liver disease. You may not be able to take acetaminophen, or you may require a dosage adjustment or special monitoring during treatment if you have either of these conditions.

Acetaminophen is in the FDA pregnancy category B. This means that it is unlikely to be harmful to an unborn baby. Do not take acetaminophen without first talking to your doctor if you are pregnant. Acetaminophen passes into breast milk. It appears to be safe for use during breast-feeding but should be avoided if possible. Talk to your doctor before taking acetaminophen if you are breast-feeding a baby.

If you are treating a child, read the package carefully and use a pediatric form of the medication if possible. Talk to a doctor first if the child is younger than 2 years of age.

How should I take acetaminophen?

Take acetaminophen exactly as directed by your doctor or follow the instructions on the package. If you do not understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you. Take each oral dose with a full glass of water. To ensure that you get a correct dose, measure the liquid forms of acetaminophen with a special dose-measuring spoon or cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist where you can get one. Shake the liquid well before measuring.

Never take more acetaminophen than is directed. The maximum amounts for adults are 1 gram (1000 mg) per dose and 4 grams (4000 mg) per day. Taking more acetaminophen could be damaging to the liver. If you drink more than three alcoholic beverages per day, talk to your doctor before taking acetaminophen.

Use acetaminophen for up to 3 days for fever or up to 10 days for pain (or up to 5 days to treat a child's pain). If the symptoms do not improve, or if they get worse, stop using acetaminophen and see a doctor.

If you are treating a child, read the package carefully and use a pediatric form of the medication if possible. Talk to a doctor first if the child is younger than 2 years of age. Store acetaminophen at room temperature away from heat, moisture, and the reach of children.

What happens if I miss a dose?

If you are taking acetaminophen on a regular schedule, take the missed dose as soon as you remember. Wait the prescribed amount of time or as directed in the package labeling before taking another dose. Do not take a double dose.

If you are taking acetaminophen on an as-needed basis, missing a dose is not usually a problem. Take the dose as soon as you remember, and do not take another dose for the amount of time prescribed or as directed in the package labeling.

What happens if I overdose?

Seek emergency medical attention.

Symptoms of an acetaminophen overdose include nausea, vomiting, diarrhea, abdominal pain, sweating, seizures, confusion, and an irregular heartbeat.

What should I avoid while taking acetaminophen?

Avoid alcohol during treatment with acetaminophen. Together, alcohol and acetaminophen can be damaging to the liver. Be aware of the acetaminophen content of other over-the-counter and prescription products. Care should be taken to avoid taking more than the recommended amount of acetaminophen per dose or per day.

What are the possible side effects of acetaminophen?

If you experience any of the following rare but serious side effects, stop taking acetaminophen and seek emergency medical attention or contact your doctor immediately:

  • an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);
  • liver damage (yellowing of the skin or eyes, nausea, abdominal pain or discomfort, unusual bleeding or bruising, severe fatigue);
  • blood problems (easy or unusual bleeding or bruising).

Other, less serious side effects are not known to occur. Side effects other than those listed here may occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect acetaminophen?

Be aware of the acetaminophen content of other over-the-counter and prescription products. Care should be taken to avoid taking more than the recommended amount of acetaminophen per dose or per day. Acetaminophen may cause false urine glucose test results. Talk to your doctor if you have diabetes and you notice changes in your glucose levels while taking acetaminophen.

Other medications may interact with acetaminophen. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including herbal products while taking acetaminophen.

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