Case Evaluation

Bextra: Bextra Overview

Bextra, a cox-2 inhibitor drug manufactured by drugs giant Pfizer, was approved for use in the US in November 2001 by the Food and Drugs Administration. Bextra was one of a number of cox-2 inhibitors that were approved to treat osteoarthritis, menstrual cramps, and adult pain. It is alleged that at the time of approval, the FDA were aware of some serious skin-related side effects that could occur from using the drug. Nevertheless, approval was given and the drug was welcomed by medics and patients all over the country. They were able to offer the benefits of traditional non-steroidal anti-inflammatory drugs, but without the associated stomach problems. This was because traditional non-steroid anti-inflammatory drugs affected the cox-1 enzyme as well as the cox-2. Since the cox-1 enzyme is required to protect the stomach lining, this often resulted in massive stomach problems in patients. However, Bextra and other cox-2 inhibitors (such as Vioxx) were able to selectively affect the cox-2 inhibitor without affecting the cox-1, which meant a massive reduction of stomach problems.

The recent withdrawal of another cox-2 inhibitor, Vioxx, has created a wave of concern about the dangers of Bextra and other cox-2s. Vioxx, which was manufactured and voluntarily recalled by manufacturing giant, Merck, was found to result in a dramatically increased risk of heart attacks and strokes in patients. There are no concerns – and allegedly some preliminary evidence – to show that Bextra may be linked to these deadly side effects in the same way as Vioxx.

Bextra has been prescribed to millions of patients over the years, and despite the potential risks of deadly skin diseases and now the possible link with heart attacks and strokes, is still freely available. In the meantime, the lawsuits and compensation claims against Pfizer continue to mount as an increasing number of patients suffer the various side effects of taking this drug.

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